There are no known drug interactions with the ingredients in MODER8®. All of the ingredients are naturally occurring in the body except for Theanine, which is the calming ingredient found in green tea. However, the formulation does contain a small amount (35 mg) of 5-HTP. There is a possibility that higher levels of 5-HTP could intensify the sedative effects of MAO inhibitors, anti-depressants and blood pressure medication. It is best to talk with your doctor or pharmacist about taking MODER8 if you are currently taking prescription medication.